Pesy is a CLI utility available from NPM that you can use to generate a ReasonML project that is ready for native compilation. It uses esy for the management of opam packages. It uses Dune for building your library code with the ReasonML and OCaml dependencies.
Assuming you already have pesy installed globally, create a directory for your project and then run:
$pesy
A project will be generated that is out-of-the-box ready to compile native executables.